Scientific file / structure
Scientist: |
DURAND Eric DURAND Eric, DURAND Eric, |
Address: |
31, chemin Jospeh Aiguier, 13009 MARSEILLE https://ericdurand3.wixsite.com/vn2m |
Area of intervention: |
Antibiotics and alternative therapies, Bioinformatics - modeling - structure, Microbial defense mechanisms, Microorganisms and host interactions/response, Pathology, Bacterial strains
Acinetobacter, Adhesion to surfaces, Therapeutic alternatives, Screening, Crystallography and structural biology, Drug development, Virulence factors, Health-care associated infections, Membrane and bacterial wall, Pseudomonas aeruginosa |
Unity; |
Laboratoire d'Ingénierie des Systèmes Macromoléculaires |
Team name: |
VirulenceNano-Macromolecular Machinosome |
Responsible:
|
STURGIS James |
Type of structure: |
Academic |
Affiliation: |
CNRS, INSERM |
Region: |
/ |
City: |
Marseille |
Description: |
The strategy we propose to engage is equivalent to a grain of sand in the T6SS gears. The final goal of our project is to target the assembly of the T6SS nanomachine with small molecule or peptide inhibitors. By sabotaging the nanomachine assembly, these future anti-T6SS drugs will be instrumental to block the virulence of Gram negative bacterial pathogens in the context of the antibiotics multi-resistance (AMR) crisis. |