These three projects are an excellent opportunity to structure research on antimicrobial resistance in metropolitan France and overseas departments and territories:
- development of a common portal allowing the interconnection and interoperability of data and analysis tools related to antimicrobial resistance,
- pooling professional skills from the three sectors of human health, animal health and the environment by facilitating sharing of skills,
- collaboration between the different sectors of research in social sciences and public health.
In the long term, these structuring projects will strengthen interactions between French research teams mobilised and recognised on the international scene in the fight against antimicrobial resistance.
ABRomics-PF: a numerical platform on antimicrobial resistance to store, integrate, analyse and share multi-omics data
Coordinators: Claudine MEDIGUE and Philippe GLASER Supporting institutions: French Institute of Bioinformatics (IFB), Institut Pasteur (IP)
Partners: 45 partner teams from 10 main institutions/agencies (Anses, BioPark, CEA, CNR-SpF, CNRS, IFB, Inrae, Inserm, IP, IRD)
Budget: €2 M
Genomics and other omics approaches are essential for research, to improve surveillance of antibiotic resistance from a One Health perspective and to develop new therapeutic strategies. The integration and analysis of omics data with associated metadata requires the development of databases accessible to the community, the use of standardised pipelines for the analysis of these data, and the development of new bioinformatics and mathematical methods. This would meet the demands of all actors involved in the problem of antibiotic resistance, such as clinical and veterinary microbiology laboratories, surveillance and public health institutes, and researchers in human, animal and environmental sectors. To meet these ambitious objectives, a multidisciplinary consortium of 43 teams belonging to the main French research organisations has been established. These teams cover the diversity of research on antimicrobial resistance in the clinical and fundamental fields and gather the skills and expertise in computer science, bioinformatics, databases, computing architecture and mathematical modelling, required to build the ABRomics-PF platform.
The development of ABRomics-PF is based on 3 technology work packages (IT infrastructure, integrated multiomics databases and bioinformatics tools) that will be developed in the context of several specific case studies. ABRomics-PF will increase the accessibility of antimicrobial resistance resources and opportunities for data exploitation. This will both enhance surveillance in France and boost research in a holistic, cross-sectoral approach.
PROMISE: Professional community network on antimicrobial resistance
Coordinators: Marie-Cécile PLOY and Bruno FRANÇOIS
Supporting institutions: Inserm UMR 1092, CHU and CIC1435 of Limoges
Partners: 30 existing professional networks, 42 academic partners and 2 new professional networks
Budget: €1.4 M
As microbes know no borders, antimicrobial resistance (AMR) can move freely from one reservoir to another and cannot be contained within one geographical region or country. The fight against AMR is not limited to the appropriate use of antimicrobials, it includes actions to reduce the negative impact of antimicrobial use on the environment and water quality. A multisectoral One Health approach is the only effective mean to limit the emergence of resistance.
By bringing together the main French actors in the AMR field (21 existing professional networks and 42 university research units in human, animal and environmental sectors), the objective of the PROMISE project is to foster synergies by establishing a One Health community that will enable networks/academic teams to share best practices and expertise, and to coordinate their actions.
PROMISE’s action is based on 4 transdisciplinary and intersectoral pillars: i) strengthening synergies to improve One Health surveillance of antibiotic consumption and AMR, ii) data sharing to improve professionals’ knowledge, iii) improving clinical research, iv) European outreach of the meta-network.
To achieve this, PROMISE aims to create a data warehouse gathering surveillance data from the 3 sectors, which will allow better understanding of the epidemic risk and reinforce the knowledge and skills of the network professionals. PROMISE will facilitate the structuring of a new network dedicated to the environment, which will collaborate closely with existing networks. Involved professionals are already working on the risk of dissemination of pathogens/AMR in the environment, however, they lack structure. PROMISE will also serve as an incubator for the emergence of networks. An open discussion forum will allow building bridges between the different scientific communities. Lastly, PROMISE will participate in training and outreach activities to strengthen One Health practices and raise awareness of the problem of AMR.
In summary, PROMISE proposes to establish fruitful multi-sectoral collaborations between actors currently working in silos by inviting them to share best practices, expertise and methodologies, to accelerate interdisciplinary and coordinated research on AMR.
DOSA – Digital Observatory of Social dimensions of Antimicrobial resistance
Coordinator: Nicolas FORTANE
Supporting institutions: Inrae CNRS UMR IRISSO, Université Paris-Dauphine
5 partner teams: Sciences Po, Télécom Paris Tech (IDF), Cirad (Montpellier) & Pfizer France
Budget : €600 k
DOSA, the Digital Observatory of Social dimensions of Antimicrobial resistance (AMR), aims to provide knowledge on
AMR-related practices, discourses and norms. It is now recognised that social sciences focusing on AMR must be
developed to better identify and evaluate the social, economic and cultural dimensions of antibiotic use and its
consequences for human and animal health and the environment. DOSA aims to stimulate this dynamic by analysing
sociological and digital data that have never been apprehended before, in order to structure a network of social
science expertise that could engage in interdisciplinary collaborations or with stakeholders. Firstly, strategic intelligence
activities and computational analyses of AMR digital spaces will provide essential resources for understanding the socioeconomic
aspects of the problem and the technical and scientific controversies that structure it. By exploring media,
scientific arenas, and social networks in all their variety, DOSA will produce data capable of capturing the different
frameworks and experiences of AMR. Secondly, communication and dissemination activities will make this knowledge
available to structure disciplinary and interdisciplinary research communities (fostering interactions between social
sciences and biomedical and veterinary sciences) and promote the prudent use of antibiotics among communities
(patients, health professionals, industries, etc.).