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Scientific literature watch

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In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris

Clinical Microbiology and Infection • 2021.12.12

Rybak J.M., Barker K.S., Muñoz J.F., et al.

Bacterial mechanisms, New antibiotics and alternatives
International
Amphotericin B, Candida auris, ERG6, In vivo evolution

Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5

Nature • 2021.09.06

Harris A., Wagner M., Du D., et al.

Bacterial mechanisms
International
Antifungal compounds, Cryoelectron microscopy, Efflux mechanism, Membrane proteins, Permeation and transport, Pleiotropic drug resistance

SCCmec amplification as a mechanism for ceftobiprole resistance in clinical MRSA isolates

Clinical Microbiology and Infection • 2022.03.31

Zhu F., Zhuang H., Di L., et al.

Bacterial mechanisms, New antibiotics and alternatives
International
Amplification, Ceftobiprole, MRSA, Nanopore-sequencing, SCCmec

Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance

Nat Chem Biol • 2021.01.18

Svetlov M.S., Syroegin E.A., Aleksandrova E.V. , et al.

Bacterial mechanisms, New antibiotics and alternatives
International
Chemical modification, Macrolides, RNA, RNA modification, Translation, X-ray crystallography

A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance

Cell • 2020.06.03

Martin J.K. 2nd, Sheehan J.P., Bratton B.P., et al.

New antibiotics and alternatives
International
Cell wall, Drug discovery, Gram-negative bacteria, Metabolism

Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin

Antibiotics • 2020.09.18

Hennessen F. , Miethke M., Zaburannyi N., et al.

NMR reveals the interplay between SilE and SilB model peptides in the context of silver resistance

Chemical Communications • 2021.08.09

Babel L., Nguyen M.H., Mittelheisser C., et al.

Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance

Cell. Mol. Life Sci. • 2021.02.17

Manniello, M.D., Moretta, A., Salvia, R. et al.

Environment, New antibiotics and alternatives
International
Antibacterial peptides, Immune system, Mechanism of action, Signaling pathways

High-density transposon libraries utilising outward-oriented promoters identify mechanisms of action and resistance to antimicrobials

FEMS Microbiol Lett. • 2020.12.14

Coward C. , Dharmalingham G, , Abdulle O., et al.

Class C β-Lactamases: Molecular Characteristics

Microbiol Rev. • 2022.04.18

Philippon A,, et al.

Bacterial mechanisms

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