Scientist: |
BRISSE Sylvain |
Address: |
/ https://research.pasteur.fr/fr/team/biodiversity-and-epidemiology-of-bacterial-pathogens/ |
Area of intervention: |
Antibiotics and alternative therapies, Biomarkers, Genetics and genomics, Technological innovations and "omics", Microbial defense mechanisms, Microorganisms and host interactions/response, One Health Sectors, Bacterial strains
Antibiotic resistance acquisition, Genotypic and phenotypic adaptations, Omic approaches, Bacteriophage and phagotherapy, Biodiversity, Bioinformatics and data mining, Corynebacterium diphtheriae, Diffusion - dissemination - transmission of antibiotic resistance, Emergence of antimicrobial resistance, Enterobacteriaceae, Evolution and phylogeny, Virulence factors, Genetics and genomics, Host-pathogen interactions, Klebsiella, Ion channel flux mechanisms, Metabolism, Microbiome - microbiota and ecology, One Health |
Unity; |
Unité Biodiversité et Epidémiologie des Bactéries Pathogènes |
Team name: |
/ |
Responsible:
|
BRISSE Sylvain |
Type of structure: |
Academic |
Affiliation: |
Institut Pasteur / CNRS UMR 3525 |
Region: |
IDF |
City: |
Paris |
Other contact: |
MOULHERAT Isabelle |
Description: |
Our lab is interested in the diversity, evolution and epidemiology of bacterial pathogens and in the links between the genotypic and phenotypic (ecology, colonization, transmission, virulence, antibiotic resistance, immune response) diversity of the strains within particular species. We focus on three pathogens of high public health importance: Klebsiella pneumoniae, which causes various types of infections including urinary tract, respiratory and blood infections; Bordetella pertussis, the agent of whooping cough; and Corynebacterium diphtheriae, the agent of diphtheria. We use genomics, proteomics, bioinformatics and immunological approaches as well as in-vivo and in-vitro models of infection. We also develop databases of bacterial genotypes and strain nomenclatures that facilitate global collaborative surveillance of bacterial pathogens. |
Scientific file / structure