Postdoc position in molecular biology and bioinformatics to study the antibiotic resistance reservoir in the environment, Université de limoges (87)

Employeur

Unité mixte de recherche 1092 Inserm, Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques

Poste et missions

« High-throughput identification of antibiotic resistance progenitors across interconnected settings: PRE-EMPT», ANR project.

The environment constitutes both a receptor and a source of antibiotic resistance determinants. Although we know that the environment contains many antibiotic resistance genes (ARGs), its role on the mobilization, selection, persistence of ARGs is still poorly understood. The PRE-EMPT project aims at identifying the reservoir of genetic structures hosting ARG across a variety of hosts, potentially transferable to pathogens, in aquatic environments from different origins. It aims at connecting the ARGs, their genetic context and their bacterial hosts by combining high-throughput sequencing based techniques.

The postdoctoral fellow will be involved in a highly collaborative ANR project involving 4 teams from Inserm, ANSES, INRAE and Pasteur Institute.

• The recruited postdoc will be in charge of the sampling water campaign, the improvement of a recently developed workflow combining metagenomic focused on integrons and bioinformatic tools to identify antibiotic resistance genes, and the analysis of the resistome of the samples.

• She/He will work closely in collaboration with a research engineer.

• She/he will also interact with partner 2 (Pasteur Institute) on the analysis of DNA captured metagenome sequences.

• General responsibilities include design, implement and interpret experiments, and bioinformatics pipeline, both independently and in collaboration, and communicate research and findings in a clear and concise manner.

The postdoctoral fellow will present the progress of the project during lab meetings, as well as during national and international conferences.

Mobilité géographique : nationale

Profil

• Expertise in molecular biology and bioinformatics will be highly prioritized

• Knowledge in quantitative PCR, and general lab protocols and methodologies used in the

biological sciences

• Strong computer literacy. Mastery of R would be a plus

• Strong interpersonal and mentoring skills needed to effectively deal with students and people of the collaborating groups

• High levels of initiative, autonomy and the ability to assume a high level of responsibility

• Hands-on experience on qPCR and molecular biology experiments,

• Experience in bioinformatics, statistical analysis

• Experience in editing and writing original research articles and grant applications is an asset

Objectifs

• The recruited postdoc will be in charge of the sampling water campaign, the improvement of a recently developed workflow combining metagenomic focused on integrons and bioinformatic tools to identify antibiotic resistance genes, and the analysis of the resistome of the samples.

• She/He will work closely in collaboration with a research engineer.

• She/he will also interact with partner 2 (Pasteur Institute) on the analysis of DNA captured metagenome sequences.

Pour postuler

Candidature à déposer sur le site de l’Association Bernard Grégory ou sur Indeed.fr.